|Statement||edited by Pieter Brakman and Cornelis Kluft.|
|Series||Annals of the New York Academy of Sciences,, v. 667|
|Contributions||Brakman, Pieter., Kluft, Cornelis, 1946-, New York Academy of Sciences.|
|LC Classifications||Q11 .N5 vol. 667, QP93.5 .N5 vol. 667|
|The Physical Object|
|Pagination||xiv, 459 p. :|
|Number of Pages||459|
|ISBN 10||089766731X, 0897667328|
|LC Control Number||92048932|
Plasminogen Activation in Fibrinolysis, in Tissue Remodeling, and in Development. Editors P. Brakman and C. Kluft Article type: Book Review. DOI: /CH For editorial issues, permissions, book . BOOK REVIEW PLASMINOGEN ACTIVATION IN FIBRINOLYSIS, IN TISSUE REMODELING, AND IN DEVELOPMENT P. Brakman, C. Kluft (Eds) Annals of the New York Academy of Sciences, Vol. , . The activated phenotype is characterized by the expression of von Willebrand factor, prostacyclin, thrombomodulin, tissue-type plasminogen activator (t-PA, M r 71 ) and plasminogen activator Author: E. Anglés-Cano. PAI-1 also has a role in tissue remodeling by interfering with vitronectin-dependent processes of cell adhesion and migration. Congenital deficiency of PAI-1 is rare, with homozygous individuals displaying abnormal bleeding in response to trauma. Platelets contribute to the fibrinolytic process by binding t-PA and plasminogen.
Plasminogen activation is essential for fibrinolysis – the breakdown of fibrin polymers in blood clots. Besides this important function, plasminogen activation participates in a wide variety of inflammatory conditions. One of these conditions is hereditary angioedema (HAE), a rare disease with characteristic attacks of aggressive tissue . beyond fibrinolysis and include promotion of angiogenesis, chemot-axis, hematopoiesis, and cellular differentiation, revealing an es - sential role in musculoskeletal repair and maintenance. Importantly, because of these diverse functions, plasminogen activation . Fibrinolysis is subject to precise control because of the actions of multiple activators, inhibitors, and cofactors. 1 In addition, receptors expressed by endothelial, monocytoid, and myeloid cells provide . Olga Amengual, Tatsuya Atsumi, in Systemic Lupus Erythematosus, aPL and the Fibrinolytic System. Fibrinolysis is a tightly regulated process by which fibrin-rich thrombus is remodeled and degraded. The fibrinolytic system involves the conversion of plasminogen to plasmin from plasminogen by the tissue-type plasminogen activator (tPA) or urokinase-type plasminogen .
1. Author(s): Brakman,Pieter; Kluft,Cornelis,; New York Academy of Sciences. Title(s): Plasminogen activation in fibrinolysis, in tissue remodeling, and in development/ edited by . Urokinase-type plasminogen activator (u-PA) is a serine protease that cleaves plasminogen to form plasmin . The u-PA/plasmin system has been implicated in a number of processes, including fibrinolysis, cell migra-tion, cell activation, and tissue remodeling (directly or indirectly via matrix metalloproteinase [MMP] activa-tion. A. Takada, Y. Sugawara, and Y. Takada, Comparison of kinetic parameters of the activation of Glu-plasminogen by tissue plasminogen activator obtained from various sources, Haemostasis, . N2 - Plasminogen (Plg) is the zymogen form of the serine protease plasmin (Plm), and it plays a crucial role in fibrinolysis as well as wound healing, immunity, tissue remodeling and inflammation. Binding to the targets via the lysine-binding sites allows for Plg activation by plasminogen .